This paper explores the potential of Izmir Adnan Menderes Airport (ADB) to use intermodality as a way to expand its catchment area into the Greek Eastern Aegean Islands using Chios as a case study. The work draws first on secondary data on travel time and transport costs to develop scenarios concerning a roundtrip from the island of Chios to ten main European cities, with flights from Athens International Airport (ATH) and ADB. Subsequently, the paper undertakes primary data analysis aiming to study airport choice between ADB and ATH by Chios inhabitants. The research findings suggest that ADB was the clear preference of respondents compared to ATH in the majority of cases, i.e. crossing the Greek-Turkish border did not prove a deterrent. This has important policy implications for tourism development provided that the current détente in the Greek-Turkish political relations continues in the future.